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1Influence of medication adherence on prostate cancer symptom control in patients undergoing radiation therapy: a prospective pilot study.
Many studies have shown the association between medication adherence and overall health. However, the impact of medication adherence on symptom control in patients with prostate cancer (CaP) undergoing radiation therapy (RT) is unclear. Therefore, we aimed to evaluate the association between medication adherence and RT-related symptoms using the Medication Adherence Report Scale (MARS)-8 in patients with CaP undergoing RT. A prospective pilot study of patients with CaP undergoing radical RT. Self-administered MARS-8 at baseline (prior to RT) and at 6-month follow-up. A total of 40 patients completed the study. On univariate analysis, satisfaction with medical care was significantly associated with medication adherence (P = 0.006), whereas satisfaction with RT was not. The mean MARS-8 score at 6-month follow-up was significantly higher than that at baseline (29.1 vs. 23.6, P = 0.002). The mean total score at baseline and at 6-month follow-up was similar (29.1 and 30.3, respectively, P = 0.130). The percentage of patients with improved symptoms at 6-month follow-up was significantly higher than that at baseline (73% vs. 40%, P = 0.026). On multivariate analysis, improvement in RT-related symptoms at 6-
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Using a rapid filtration technique, we measured Na(+)-H+ exchange activity in rat mammary gland plasma membrane vesicles (PMV) isolated during lactation (Liv), pregnancy (Preg), postpartum (PP) and after pregnancy (B1, B2, B3). PMV isolated during B1 and PP have the highest Na(+)-H+ exchange activity (about 160 mueq/mg protein/15 s), while those isolated during Preg, Liv and B2 have similar Na(+)-H+ exchange activity (120 mueq/mg protein/15 s). In contrast, the Na(+)-H+ exchange activity in PMV isolated during B2 and B3 (80 mueq/mg protein/15 s) is significantly lower than that of Preg and PP-PMV. In addition, the affinity (K0.5) and Hill coefficient (nH) of Na(+)-H+ exchange in PMV from B2 and B3 (K0.5 = 400 nm; nH = 0.9) are similar to those in PMV from Preg and PP (K0.5 = 330 nm; nH =